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"score": { "earned": 100, "total": 100, "weight": 10 }, "test_status": "pass" }, "rda_a2_01m": { "color": "#2ECC71", "msg": [ { "message": "DIGITAL.CSIC preservation policy is available at: https://digital.csic.es/dc/politicas/#politica8", "points": 100 } ], "name": "rda_a2_01m", "points": 100, "score": { "earned": 100, "total": 100, "weight": 20 }, "test_status": "pass" } }, "findable": { "rda_f1_01d": { "color": "#2ECC71", "msg": [ { "message": "Found persistent identifier for the data: 10.1038/s41419-026-08632-1", "points": 100 }, { "message": "Found persistent identifier for the data: http://hdl.handle.net/10261/436314", "points": 100 }, { "message": "Found persistent identifier for the data: https://doi.org/10.1038/s41419-026-08632-1", "points": 100 }, { "message": "Found persistent identifier for the data: info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142971OB-I00/ES/NUCLEOTIDO HIDROLASAS EN LA INFECCION POR 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Data: purl.org/coar", "points": 100 } ], "name": "rda_i1_01m", "points": 100, "score": { "earned": 100, "total": 100, "weight": 15 }, "test_status": "pass" }, "rda_i1_02d": { "color": "#2ECC71", "msg": [ { "message": "Machine-actionable metadata format found: rdf", "points": 100 }, { "message": "After applying weigh", "points": 100.0 } ], "name": "rda_i1_02d", "points": 100.0, "score": { "earned": 100.0, "total": 100, "weight": 15 }, "test_status": "pass" }, "rda_i1_02m": { "color": "#2ECC71", "msg": [ { "message": "Machine-actionable metadata format found: rdf", "points": 100 }, { "message": "After applying weigh", "points": 100.0 } ], "name": "rda_i1_02m", "points": 100.0, "score": { "earned": 100.0, "total": 100, "weight": 15 }, "test_status": "pass" }, "rda_i2_01d": { "color": "#2ECC71", "msg": [ { "message": "Controlled vocabulary purl.org/coar has PID purl.org/coar", "points": 100 } ], "name": "rda_i2_01d", "points": 100, "score": { "earned": 100, "total": 100, "weight": 10 }, "test_status": "pass" }, "rda_i2_01m": { "color": "#2ECC71", "msg": [ { "message": "Controlled vocabulary purl.org/coar has PID purl.org/coar", "points": 100 } ], "name": "rda_i2_01m", "points": 100, "score": { "earned": 100, "total": 100, "weight": 15 }, "test_status": "pass" }, "rda_i3_01d": { "color": "#2ECC71", "msg": [ { "message": "References to related object: info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142971OB-I00/ES/NUCLEOTIDO HIDROLASAS EN LA INFECCION POR TRYPANOSOMA. ELUCIDACION DE SU PAPEL EN LAS INTERACCIONES HUESPED-PARASITO/", "points": 100 }, { "message": "References to related object: info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142971OB-I00/ES/NUCLEOTIDO HIDROLASAS EN LA INFECCION POR TRYPANOSOMA. ELUCIDACION DE SU PAPEL EN LAS INTERACCIONES HUESPED-PARASITO/", "points": 100 }, { "message": "References to related object: Fernández López, María Belén [0000-0001-9987-1495]", "points": 100 }, { "message": "References to related object: Vidal, Antonio E. [0000-0001-9491-8901]", "points": 100 }, { "message": "References to related object: Ministerio de Ciencia e Innovación (España)", "points": 100 }, { "message": "References to related object: Agencia Estatal de Investigación (España)", "points": 100 }, { "message": "References to related object: Junta de Andalucía", "points": 100 }, { "message": "References to related object: European Commission", "points": 100 } ], "name": "rda_i3_01d", "points": 100, "score": { "earned": 100, "total": 100, "weight": 10 }, "test_status": "pass" }, "rda_i3_01m": { "color": "#2ECC71", "msg": [ { "message": "Qualified references to related object: http://dx.doi.org/10.13039/501100000780", "points": 100 }, { "message": "Qualified references to related object: http://dx.doi.org/10.13039/501100004837", "points": 100 }, { "message": "Qualified references to related object: http://dx.doi.org/10.13039/501100011011", "points": 100 }, { "message": "Qualified references to related object: http://dx.doi.org/10.13039/501100011033", "points": 100 }, { "message": "Qualified references to related object: Fernández López, María Belén [0000-0001-9987-1495]", "points": 100 }, { "message": "Qualified references to related object: Vidal, Antonio E. [0000-0001-9491-8901]", "points": 100 }, { "message": "Qualified references to related object: Ministerio de Ciencia e Innovación (España)", "points": 100 }, { "message": "Qualified references to related object: Agencia Estatal de Investigación (España)", "points": 100 }, { "message": "Qualified references to related object: Junta de Andalucía", "points": 100 }, { "message": "Qualified references to related object: European Commission", "points": 100 }, { "message": "Qualified references to related object: info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142971OB-I00/ES/NUCLEOTIDO HIDROLASAS EN LA INFECCION POR TRYPANOSOMA. 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ELUCIDACION DE SU PAPEL EN LAS INTERACCIONES HUESPED-PARASITO/", "points": 100 }, { "message": "References to related object: Fernández López, María Belén [0000-0001-9987-1495]", "points": 100 }, { "message": "References to related object: Vidal, Antonio E. [0000-0001-9491-8901]", "points": 100 }, { "message": "References to related object: Ministerio de Ciencia e Innovación (España)", "points": 100 }, { "message": "References to related object: Agencia Estatal de Investigación (España)", "points": 100 }, { "message": "References to related object: Junta de Andalucía", "points": 100 }, { "message": "References to related object: European Commission", "points": 100 } ], "name": "rda_i3_02d", "points": 100, "score": { "earned": 100, "total": 100, "weight": 10 }, "test_status": "pass" }, "rda_i3_02m": { "color": "#2ECC71", "msg": [ { "message": "References to related object: info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142971OB-I00/ES/NUCLEOTIDO HIDROLASAS EN LA INFECCION POR TRYPANOSOMA. ELUCIDACION DE SU PAPEL EN LAS INTERACCIONES HUESPED-PARASITO/", "points": 100 }, { "message": "References to related object: info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142971OB-I00/ES/NUCLEOTIDO HIDROLASAS EN LA INFECCION POR TRYPANOSOMA. ELUCIDACION DE SU PAPEL EN LAS INTERACCIONES HUESPED-PARASITO/", "points": 100 }, { "message": "References to related object: Fernández López, María Belén [0000-0001-9987-1495]", "points": 100 }, { "message": "References to related object: Vidal, Antonio E. [0000-0001-9491-8901]", "points": 100 }, { "message": "References to related object: Ministerio de Ciencia e Innovación (España)", "points": 100 }, { "message": "References to related object: Agencia Estatal de Investigación (España)", "points": 100 }, { "message": "References to related object: Junta de Andalucía", "points": 100 }, { "message": "References to related object: European Commission", "points": 100 } ], "name": "rda_i3_02m", "points": 100, "score": { "earned": 100, "total": 100, "weight": 10 }, "test_status": "pass" }, "rda_i3_03m": { "color": "#2ECC71", "msg": [ { "message": "References to related object: info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142971OB-I00/ES/NUCLEOTIDO HIDROLASAS EN LA INFECCION POR TRYPANOSOMA. ELUCIDACION DE SU PAPEL EN LAS INTERACCIONES HUESPED-PARASITO/", "points": 100 }, { "message": "References to related object: info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142971OB-I00/ES/NUCLEOTIDO HIDROLASAS EN LA INFECCION POR TRYPANOSOMA. ELUCIDACION DE SU PAPEL EN LAS INTERACCIONES HUESPED-PARASITO/", "points": 100 }, { "message": "References to related object: Fernández López, María Belén [0000-0001-9987-1495]", "points": 100 }, { "message": "References to related object: Vidal, Antonio E. [0000-0001-9491-8901]", "points": 100 }, { "message": "References to related object: Ministerio de Ciencia e Innovación (España)", "points": 100 }, { "message": "References to related object: Agencia Estatal de Investigación (España)", "points": 100 }, { "message": "References to related object: Junta de Andalucía", "points": 100 }, { "message": "References to related object: European Commission", "points": 100 } ], "name": "rda_i3_03m", "points": 100, "score": { "earned": 100, "total": 100, "weight": 15 }, "test_status": "pass" }, "rda_i3_04m": { "color": "#2ECC71", "msg": [ { "message": "References to related object: info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142971OB-I00/ES/NUCLEOTIDO HIDROLASAS EN LA INFECCION POR TRYPANOSOMA. ELUCIDACION DE SU PAPEL EN LAS INTERACCIONES HUESPED-PARASITO/", "points": 100 }, { "message": "References to related object: info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142971OB-I00/ES/NUCLEOTIDO HIDROLASAS EN LA INFECCION POR TRYPANOSOMA. ELUCIDACION DE SU PAPEL EN LAS INTERACCIONES HUESPED-PARASITO/", "points": 100 }, { "message": "References to related object: Fernández López, María Belén [0000-0001-9987-1495]", "points": 100 }, { "message": "References to related object: Vidal, Antonio E. [0000-0001-9491-8901]", "points": 100 }, { "message": "References to related object: Ministerio de Ciencia e Innovación (España)", "points": 100 }, { "message": "References to related object: Agencia Estatal de Investigación (España)", "points": 100 }, { "message": "References to related object: Junta de Andalucía", "points": 100 }, { "message": "References to related object: European Commission", "points": 100 } ], "name": "rda_i3_04m", "points": 100, "score": { "earned": 100, "total": 100, "weight": 10 }, "test_status": "pass" } }, "reusable": { "rda_r1_01m": { "color": "#F4D03F", "msg": [ { "message": "Found 18 metadata elements that enhance reusability: ['Vidal, Antonio E.', 'Fernández, Belén', 'Martínez-Arribas, Blanca', 'Pérez-Moreno, Guiomar', 'Ruiz-Pérez, Luis Miguel', 'González-Pacanowska, Dolores', '2026-03-26', 'DCTPP1 orchestrates dCTP pool dynamics and mtDNA stability in quiescent cells', 'Cell Death and Disease 17: 404 (2026)', 'http://hdl.handle.net/10261/436314', 'Springer Nature', 'Cell Death and Disease 17: 404 (2026)', 'http://hdl.handle.net/10261/436314', 'artículo', 'eng', 'Sí', 'info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142971OB-I00/ES/NUCLEOTIDO HIDROLASAS EN LA INFECCION POR TRYPANOSOMA. ELUCIDACION DE SU PAPEL EN LAS INTERACCIONES HUESPED-PARASITO/', 'openAccess']", "points": 60.0 } ], "name": "rda_r1_01m", "points": 60.0, "score": { "earned": 60.0, "total": 100, "weight": 20 }, "test_status": "indeterminate" }, "rda_r1_1_01m": { "color": "#2ECC71", "msg": [ { "message": "License found : openAccess", "points": 100 }, { "message": "License found : openAccess", "points": 100 }, { "message": "License found : http://creativecommons.org/licenses/by/4.0/", "points": 100 } ], "name": "rda_r1_1_01m", "points": 100, "score": { "earned": 100, "total": 100, "weight": 20 }, "test_status": "pass" }, "rda_r1_1_02m": { "color": "#E74C3C", "msg": [ { "message": "None of the license/s defined are standard according to SPDX license list (points: 0)", "points": 0 } ], "name": "rda_r1_1_02m", "points": 0, "score": { "earned": 0, "total": 100, "weight": 15 }, "test_status": "fail" }, "rda_r1_1_03m": { "color": "#E74C3C", "msg": [ { "message": [ { "message": "License/s arenot machine readable according to SPDX", "points": 0 } ], "points": 0 } ], "name": "rda_r1_1_03m", "points": 0, "score": { "earned": 0, "total": 100, "weight": 15 }, "test_status": "fail" }, "rda_r1_2_01m": { "color": "#E74C3C", "msg": [ { "message": "Provenance info found: Defects in nucleotide metabolism and imbalances in deoxynucleotide triphosphate (dNTP) pools are associated with several human diseases, including cancer and mitochondrial disorders. In non-replicative cells, while DNA synthesis is reduced, a continuous supply of nucleotides is essential to sustain mitochondrial DNA (mtDNA) replication and repair. Human all-α dCTP pyrophosphatase 1 (DCTPP1), a nucleotido hydrolase with high specificity for dCTP, plays a critical role in maintaining nucleotide homeostasis, however its participation in mtDNA stability remains unexplored. In this study we performed a detailed analysis of pyrimidine metabolism enzymes in non-dividing cells. We found that during quiescence, DCTPP1 is predominantly localized to mitochondria. Depletion of the enzyme leads to upregulation of the de novo thymidylate synthesis pathway and expansion of both the dCTP and dGTP pools, highlighting its pivotal role in regulating the dNTP balance. To explore the potential therapeutic relevance of these observations, we used an in vitro model of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), a rare mitochondrial disorder caused by thymidine phosphorylase (TP) deficiency and characterized by dCTP depletion and mtDNA loss. Long-term thymidine overloading in quiescent cells (a model mimicking TP deficiency) led to reduced dCTP levels and the depletion of mtDNA, effects that were reversed upon DCTPP1 knockdown. Hence, reduced DCTPP1 levels restored dCTP availability and increased mtDNA copy number. These findings suggest that DCTPP1 plays a critical role in regulating mitochondrial dNTP pools and that down-regulation of the enzyme may serve as a compensatory mechanism in disorders marked by secondary dCTP depletion. DCTPP1 may therefore represent a promising therapeutic target for mitochondrial DNA depletion syndromes such as MNGIE.", "points": 100 }, { "message": "Provenance info found: info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142971OB-I00/ES/NUCLEOTIDO HIDROLASAS EN LA INFECCION POR TRYPANOSOMA. ELUCIDACION DE SU PAPEL EN LAS INTERACCIONES HUESPED-PARASITO/", "points": 100 }, { "message": "Error checking README/CODEBOOK files for provenance: item_type must be 'doi' or 'handle'", "points": 0 } ], "name": "rda_r1_2_01m", "points": 0, "score": { "earned": 0, "total": 100, "weight": 15 }, "test_status": "fail" }, "rda_r1_2_02m": { "color": "#E74C3C", "msg": [ { "message": "Provenance info found: Defects in nucleotide metabolism and imbalances in deoxynucleotide triphosphate (dNTP) pools are associated with several human diseases, including cancer and mitochondrial disorders. 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To explore the potential therapeutic relevance of these observations, we used an in vitro model of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), a rare mitochondrial disorder caused by thymidine phosphorylase (TP) deficiency and characterized by dCTP depletion and mtDNA loss. Long-term thymidine overloading in quiescent cells (a model mimicking TP deficiency) led to reduced dCTP levels and the depletion of mtDNA, effects that were reversed upon DCTPP1 knockdown. Hence, reduced DCTPP1 levels restored dCTP availability and increased mtDNA copy number. These findings suggest that DCTPP1 plays a critical role in regulating mitochondrial dNTP pools and that down-regulation of the enzyme may serve as a compensatory mechanism in disorders marked by secondary dCTP depletion. DCTPP1 may therefore represent a promising therapeutic target for mitochondrial DNA depletion syndromes such as MNGIE.", "points": 100 }, { "message": "Provenance info found: info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142971OB-I00/ES/NUCLEOTIDO HIDROLASAS EN LA INFECCION POR TRYPANOSOMA. 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